UJI EFEK ANTIHIPERTENSI EKSTRAK ETANOL DAUN SELEDRI (Apium graveolens L. ) PADA TIKUS PUTIH JANTAN DIINDUKSI PREDNISON DAN NaCl

  • Nessa Nessa Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang
  • Sanubari Rela Tobat Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang
  • M Husni Mukhtar Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang
  • Sufi Auliya Muztika Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang
Keywords: Antihypertensive, CODA non invasive blood pressure

Abstract

This study used celery ethanol extract (Apium graveolens L. ) which is expected to reduce blood pressure in rat body previously induced with prednisone 1.5 mg / kgBW and 2.5% NaCl. The test animals were divided into 6 groups, each group consisting of 3 male white rats. Group 1 is a negative control group given susension Na CMC 0,5%. Group 2 was a positive control group given prednisone 1.5 mg / kgBW and 2.5% NaCl. Group 3, 4, 5 were treated with ethanol extract of celery leaves with 3 dose variations  (100; 200 and 400) mg / kgBW. Group 6 was the comparison group given Captopril 2.5 mg / kgBB. Treatment was performed for 10 days, observed on day 7 and 10 using a CODA Non-Invasive blood pressure gauge. From the research done in get the result of blood pressure group  leverage 1: (121,85 / 99,21 mmHg). Group 2:(159,85 / 136,25 mmHg). Group 3:(120,35 / 94,71mmHg). Group 4:(109.335 / 82.51 mmHg). Group 5:(107.59 / 74.94 mmHg)and Group 6:(117.19 / 95.94 mmHg). The results of this study showed that ethanol extract of celery leaves can lower blood pressure to normal at doses of 100 mg / KgBW compared to other doses. Based on statistical test of variance analysis using ANOVA one way, it was found that ethanol extract of celery leaves significantly affected blood pressure (P <0,05).

Author Biographies

Nessa Nessa, Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sanubari Rela Tobat, Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

M Husni Mukhtar, Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sufi Auliya Muztika, Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Sekolah Tinggi Farmasi Indonesia Yayasan Perintis Padang

Published
2018-09-04