UJI EFEK ANTIHIPERTENSI EKSTRAK ETANOL DAUN SELEDRI (Apium graveolens L.) PADA TIKUS PUTIH JANTAN DIINDUKSI PREDNISON DAN NaCl

Abstract

ABSTRACT

This study used celery ethanol extract (Apium graveolens L.) which is expected to reduce blood pressure in rat body previously induced with prednisone 1.5 mg / kgBW and 2.5% NaCl. The test animals were divided into 6 groups, each group consisting of 3 male white rats. Group 1 is a negative control group given susension Na CMC 0,5%. Group 2 was a positive control group given prednisone 1.5 mg / kgBW and 2.5% NaCl. Group 3, 4, 5 were treated with ethanol extract of celery leaves with 3 dose variations (100; 200 and 400) mg / kgBW. Group 6 was the comparison group given Captopril 2.5 mg / kgBB. Treatment was performed for 10 days, observed on day 7 and 10 using a CODA Non-Invasive blood pressure gauge. From the research done in get the result of blood pressure group average 1: (121,85 / 99,21 mmHg). Group 2: (159,85 / 136,25 mmHg). Group 3: (120,35 / 94,71 mmHg). Group 4: (109.335 / 82.51 mmHg). Group 5: (107.59 / 74.94 mmHg) and Group 6: (117.19 / 95.94 mmHg). The results of this study showed that ethanol extract of celery leaves can lower blood pressure to normal at doses of 100 mg / KgBW compared to other doses. Based on statistical test of variance analysis using ANOVA one way, it was found that ethanol extract of celery leaves significantly affected blood pressure (P <0,05).